SOX10 抗体 (AA 115-269)
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北京 101111
Quick Overview for SOX10 抗体 (AA 115-269) (ABIN7870208)
抗原
See all SOX10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 115-269
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原理
- SOX10 Antibody
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 115-269 was used as the immunogen for the SOX10 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the SOX10 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the SOX10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
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别名
- SOX10
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背景
- SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
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UniProt
- P56693
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途径
- Chromatin Binding
抗原
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