SLFN11 抗体 (AA 114-794)
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Quick Overview for SLFN11 抗体 (AA 114-794) (ABIN7870195)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 114-794
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原理
- SLFN11 Antibody / Schlafen family member 11
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids P114-D794) was used as the immunogen for the SLFN11 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the SLFN11 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SLFN11 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SLFN11 (Schlafen Family Member 11 (SLFN11))
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别名
- SLFN11
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背景
- Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.
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UniProt
- Q7Z7L1
抗原
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