TFPI2 抗体 (AA 100-235)
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北京 101111
Quick Overview for TFPI2 抗体 (AA 100-235) (ABIN7869769)
抗原
See all TFPI2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-235
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原理
- TFPI2 Antibody / Tissue factor pathway inhibitor 2
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纯化方法
- Protein G affinity
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免疫原
- A portion of amino acids 100-235 from human Tissue factor pathway inhibitor 2 protein was used as the immunogen for the TFPI2 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the TFPI2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the TFPI2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))
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别名
- TFPI2
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背景
- The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII with tissue factor, a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Inhibition of Factor VIIa tissue factor activity requires a plasma component (tissue factor pathway inhibitor (TFPI), lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor (EPI)) and factor Xa. TFPI directly inhibits factor Xa, and, in an Xa-dependent fashion, also inhibits the Factor VIIa tissue factor catalytic complex. TFPI is a multivalent, Kunitz-type proteinase inhibitor that circulates in association with plasma lipoproteins VLDL, LDL, and HDL. TFPI-2 (also known as placental protein 5) is a related glycoprotein that was originally isolated from human placenta.
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UniProt
- P48307
抗原
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