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VCP 抗体 (AA 10-512)

Name: VCP 抗体 (AA 10-512)
SKU: ABIN7869710
Availability: OutOfStock

This 兔多克隆 antibody specifically detects VCP in WB 和 IHC (p). It exhibits reactivity toward 斑马鱼.

产品编号 ABIN7869710

发货至: 中国

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Quick Overview for VCP 抗体 (AA 10-512) (ABIN7869710)

抗原

See all VCP 抗体

VCP (Valosin Containing Protein (VCP))

适用

斑马鱼

宿主

兔

克隆类型

多克隆

标记

This VCP antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product VCP Primary Antibody

抗原表位
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AA 10-512

原理

Zebrafish Cdc48 Antibody / Valosin-containing protein / Vcp

纯化方法

Antigen affinity chromatography

免疫原

E. coli-derived zebrafish Cdc48 recombinant protein (amino acids D10-K512) was used as the immunogen for the Zebrafish Cdc48 antibody.

亚型

Ig Fraction
anti-Valosin Containing Protein (VCP) (C-Term) antibody
KO Validated VCP 适用: 人 WB, IF, IP, IHC (p), ICC, IHC (fro), IHC (wm) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (N-Term) antibody
VCP 适用: 人 WB, IF, IP, IHC (p), ICC, IHC (wm) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 125-371) antibody
VCP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 1-588) antibody
VCP 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4A8 unconjugated

anti-Valosin Containing Protein (VCP) (AA 647-806) antibody
VCP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) antibody
VCP 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Monoclonal 5H12 unconjugated Recombinant Antibody

anti-Valosin Containing Protein (VCP) antibody
VCP 适用: 人, 小鼠 WB, FACS, ICC 宿主: 小鼠 Monoclonal Hs-14 unconjugated

anti-Valosin Containing Protein (VCP) (AA 749-766), (C-Term) antibody
VCP 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 732-760), (C-Term) antibody
VCP 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 732-760) antibody
VCP 适用: 人, 小鼠, 大鼠 WB, IF, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the Zebrafish Cdc48 antibody should be determined by the researcher.

限制

仅限研究用
状态

Lyophilized

缓冲液

0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

储存条件

4 °C,-20 °C

储存方法

After reconstitution, the Zebrafish Cdc48 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
抗原

VCP (Valosin Containing Protein (VCP))

别名

Cdc48

背景

Zebrafish Cdc48, also known as cell division cycle 48, is a crucial ATPase that is involved in various cellular processes including protein degradation, cell cycle regulation, and membrane dynamics. Cdc48 is part of the AAA+ ATPase family and functions as a part of the 26S proteasome pathway, where it helps to extract polyubiquitinated substrates from the proteasome or other cellular compartments for degradation. Additionally, Cdc48 plays a role in endoplasmic reticulum associated degradation (ERAD), maintaining cellular homeostasis by ensuring the removal of misfolded proteins.
Zebrafish Cdc48 is an ortholog of the human CDC48 protein, also known as p97. It shares significant sequence and functional conservation with its human counterpart, ensuring that it performs similar roles in regulating protein turnover, signaling pathways, and cell cycle progression. Like human p97, zebrafish Cdc48 is essential for the regulation of processes such as DNA repair, organelle biogenesis, and apoptosis, and its dysfunction can result in various diseases, including neurodegenerative disorders and certain cancers.
The use of a Zebrafish Cdc48 antibody is an invaluable tool for studying protein quality control mechanisms and their role in cellular stress responses. Such antibodies are essential for applications including western blot, immunohistochemistry, immunofluorescence, and ELISA. With a Zebrafish Cdc48 antibody, researchers can analyze Cdc48 expression in different tissues, study its involvement in proteostasis, and investigate how alterations in its function impact development and disease.
Currently, no isoforms of zebrafish Cdc48 have been documented, but its essential role in cellular maintenance and its conservation across species make it an important target for research. A high-quality Zebrafish Cdc48 antibody provides essential insights into cellular stress mechanisms and the regulation of the ubiquitin-proteasome system in zebrafish models.

UniProt

Q7ZU99

途径

ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway