DDB2 抗体 (AA 10-424)
Our Local Distributor
北京 101111
Quick Overview for DDB2 抗体 (AA 10-424) (ABIN7869703)
抗原
See all DDB2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 10-424
-
原理
- DDB2 Antibody
-
纯化方法
- Affinity purified
-
免疫原
- Recombinant human protein (amino acids Q10-R424) was used as the immunogen for the DDB2 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the DDB2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the DDB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
-
别名
- DDB2
-
背景
- DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
-
UniProt
- Q92466
-
途径
- DNA Damage Repair
抗原
-