FAM48A/P38IP 抗体 (AA 1-713)
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Quick Overview for FAM48A/P38IP 抗体 (AA 1-713) (ABIN7869535)
抗原
See all FAM48A/P38IP (SUPT20H) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-713
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原理
- SUPT20H Antibody / Transcription factor SPT20 homolog
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SUPT20H recombinant protein (Position: M1-Q713) was used as the immunogen for the SUPT20H antibody.
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亚型
- IgG
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anti-Suppressor of Ty 20 Homolog (SUPT20H) (AA 580-779) antibody
SUPT20H 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 20 Homolog (SUPT20H) (AA 580-779) antibodySUPT20H 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 20 Homolog (SUPT20H) antibodySUPT20H 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 20 Homolog (SUPT20H) (Internal Region) antibodySUPT20H 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SUPT20H antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SUPT20H antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FAM48A/P38IP (SUPT20H) (Suppressor of Ty 20 Homolog (SUPT20H))
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别名
- SUPT20H
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背景
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SUPT20H antibody detects Transcription factor SPT20 homolog, a multifunctional protein involved in transcriptional regulation, chromatin remodeling, and proteostasis. Encoded by the SUPT20H gene on chromosome 13q12.3, this evolutionarily conserved factor plays dual roles as a component of transcriptional coactivator complexes and as a regulator of protein homeostasis in the cytoplasm. SUPT20H participates in the regulation of RNA polymerase II-mediated transcription, chromatin accessibility, and cellular stress response.
Structurally, SUPT20H contains conserved coiled-coil and low-complexity regions that facilitate interactions with chromatin-associated proteins, transcription factors, and the proteasome. It is a functional homolog of yeast SPT20, a core subunit of the SAGA (Spt-Ada-Gcn5 acetyltransferase) transcriptional coactivator complex that links histone acetylation to gene activation. In mammalian systems, SUPT20H contributes to nucleosome remodeling and transcriptional coactivation by coupling histone modification with recruitment of RNA polymerase II at promoter regions.
The SUPT20H antibody is widely used in epigenetics, gene regulation, and cell biology research to study transcriptional activation, chromatin remodeling, and stress adaptation. Western blot analysis detects a 100 kilodalton band corresponding to SUPT20H, while immunofluorescence reveals both nuclear and cytoplasmic staining, reflecting its multifunctional localization. This antibody enables researchers to investigate how chromatin dynamics and transcriptional machinery coordinate gene expression in response to cellular cues.
Beyond its nuclear role, SUPT20H interacts with the proteasome and heat shock proteins to regulate protein degradation and quality control under stress conditions. It assists in clearing misfolded proteins and maintaining cytoplasmic proteostasis. Dysregulation of SUPT20H expression or mutations affecting its protein-interaction motifs have been linked to altered transcriptional fidelity, stress sensitivity, and oncogenic transformation. The SUPT20H antibody provides a powerful tool for characterizing these processes at the molecular level. NSJ Bioreagents validates this antibody for its applications, ensuring dependable performance in transcriptional and proteostasis research. -
UniProt
- Q8NEM7
抗原
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