KAT5 抗体 (AA 1-56)
Our Local Distributor
北京 101111
Quick Overview for KAT5 抗体 (AA 1-56) (ABIN7869473)
抗原
See all KAT5 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-56
-
原理
- KAT5 Antibody / Tip60 / 60 kDa Tat-interactive protein
-
纯化方法
- Antigen affinity purified
-
免疫原
- Recombinant human protein (amino acids M1-E56) was used as the immunogen for the KAT5 antibody.
-
亚型
- IgG
-
-
anti-K(lysine) Acetyltransferase 5 (KAT5) (AA 18-208) antibody
KAT5 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2A11H7 unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (AA 3-512) antibodyKAT5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (AA 33-64), (N-Term) antibodyKAT5 适用: 人 WB 宿主: 兔 Polyclonal RB05776 unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (AA 18-208) antibodyKAT5 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4B3B4 unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) antibodyKAT5 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3F9 unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (AA 1-513) antibodyKAT5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (pSer86) antibodyKAT5 适用: 人 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (C-Term) antibodyKAT5 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 山羊, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) (AA 230-462) antibodyKAT5 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 5 (KAT5) antibodyKAT5 适用: 人 ICC, DB 宿主: 小鼠 Monoclonal 3557C4a unconjugated
-
-
应用备注
- Optimal dilution of the KAT5 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the KAT5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- KAT5 (K(lysine) Acetyltransferase 5 (KAT5))
-
别名
- KAT5
-
背景
-
KAT5 Antibody targets lysine acetyltransferase 5, a nuclear histone acetyltransferase commonly known as Tip60 and encoded by the KAT5 gene. Tip60 is a member of the MYST family of histone acetyltransferases and functions as a central regulator of chromatin structure, transcriptional regulation, and DNA damage response pathways. Through its enzymatic activity and participation in multiprotein complexes, KAT5 plays a critical role in maintaining genomic stability and coordinating nuclear signaling events in response to cellular stress.
Functionally, Tip60 catalyzes the acetylation of histone substrates, including histone H4 and histone H2A variants, leading to increased chromatin accessibility and facilitation of transcriptional activation. In addition to histones, KAT5 acetylates a range of non-histone proteins involved in DNA repair, cell cycle control, and apoptosis regulation. These acetylation events influence protein stability, protein-protein interactions, and signaling outcomes, positioning Tip60 as an integrative regulator of transcriptional and stress response networks. A KAT5 Antibody supports studies focused on epigenetic regulation, histone acetylation dynamics, and nuclear signaling mechanisms across diverse biological contexts.
KAT5 is predominantly localized to the nucleus, consistent with its role in chromatin-associated processes. Within the nucleus, Tip60 functions as part of large multiprotein assemblies that link histone acetylation with ATP-dependent chromatin remodeling, transcription factor recruitment, and DNA repair machinery. Subcellular distribution and activity of KAT5 can vary depending on cell type, developmental stage, and cellular stress conditions, reflecting dynamic regulation of its interaction partners and enzymatic function. These features highlight Tip60 as a responsive chromatin regulator rather than a static epigenetic modifier.
At the molecular level, KAT5 contains a conserved MYST acetyltransferase domain that mediates catalytic activity, along with additional regions that facilitate protein-protein interactions within chromatin-modifying complexes. Structural features of Tip60 enable coordinated regulation of acetylation events and integration with broader chromatin remodeling processes. Post-translational modifications of KAT5 itself, as well as regulated complex assembly, further fine-tune its activity and functional specificity in different cellular contexts.
From a disease relevance perspective, altered Tip60 expression or activity has been investigated in cancer, neurodegenerative disorders, and other conditions associated with genomic instability and dysregulated transcription. KAT5 has been implicated in tumor suppressor pathways through its involvement in DNA damage signaling, apoptosis regulation, and maintenance of chromatin integrity. Disruption of Tip60-mediated acetylation can affect cellular responses to genotoxic stress and influence cell fate decisions, underscoring the importance of KAT5 in preserving nuclear homeostasis. KAT5 Antibody reagents support research applications examining epigenetic control mechanisms, chromatin remodeling pathways, and DNA damage response signaling, with NSJ Bioreagents providing antibodies intended for research use. -
UniProt
- Q92993
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
-
