VANGL2 抗体 (AA 1-489)
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Quick Overview for VANGL2 抗体 (AA 1-489) (ABIN7869408)
抗原
See all VANGL2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-489
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原理
- Zebrafish Vangl2 Antibody / Vang-like protein 2
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Vangl2 recombinant protein (amino acids M1-D489) was used as the immunogen for the Zebrafish Vangl2 antibody.
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亚型
- Ig Fraction
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anti-Vang-Like 2 (VANGL2) (AA 1-110) antibody
VANGL2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 2 (VANGL2) (AA 376-410) antibodyVANGL2 适用: 人 WB 宿主: 兔 Polyclonal RB52981 unconjugated
anti-Vang-Like 2 (VANGL2) (AA 37-65), (N-Term) antibodyVANGL2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40615 unconjugated
anti-Vang-Like 2 (VANGL2) (Internal Region) antibodyVerified VANGL2 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Vang-Like 2 (VANGL2) (AA 300-350) antibodyVANGL2 适用: 人, 小鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 2 (VANGL2) (pSer79), (pSer82), (pSer84) antibodyVANGL2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Vang-Like 2 (VANGL2) (pSer79), (pSer82), (pThr78) antibodyVANGL2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Vang-Like 2 (VANGL2) (AA 37-65) antibodyVANGL2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Vangl2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Vangl2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- VANGL2 (Vang-Like 2 (VANGL2))
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别名
- Vangl2
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背景
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Van Gogh-like protein 2 (Vangl2) is a core component of the planar cell polarity (PCP) pathway, a non-canonical Wnt signaling pathway that regulates the orientation and coordinated movement of cells within the plane of a tissue. In zebrafish (Danio rerio), Vangl2 plays a vital role in embryonic morphogenesis, particularly in convergent extension movements during gastrulation, which are essential for body axis elongation.
Zebrafish vangl2 is expressed early in development and is critical for establishing tissue polarity and directional cell migration. Mutations in vangl2-such as the well-studied trilobite mutant-lead to severe defects in neural tube formation, somite patterning, and organ positioning, making it a key model for understanding PCP signaling in vertebrates.
Given its high conservation and pivotal role in developmental processes, zebrafish Vangl2 is widely used to study cell polarity, tissue architecture, and congenital disorders such as neural tube defects. It also provides valuable insights into cytoskeletal organization, cell-cell communication, and signal integration during vertebrate development.
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UniProt
- Q8UVJ6
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途径
- WNT signaling, Stem Cell Maintenance, Tube Formation, Asymmetric Protein Localization
抗原
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