Sphingomyelin Synthase 1 抗体 (AA 1-413)
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Quick Overview for Sphingomyelin Synthase 1 抗体 (AA 1-413) (ABIN7869329)
抗原
See all Sphingomyelin Synthase 1 (SGMS1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-413
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原理
- SGMS1 Antibody / Sphingomyelin synthase 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SGMS1 recombinant protein (Position: M1-T413) was used as the immunogen for the SGMS1 antibody.
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亚型
- IgG
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anti-Sphingomyelin Synthase 1 (SGMS1) (AA 331-413) antibody
SGMS1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 48-137) antibodySGMS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 1-134) antibodySGMS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 24-53), (N-Term) antibodySGMS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32319 unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) antibodySGMS1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 144-193) antibodySGMS1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (Middle Region) antibodySGMS1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SGMS1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SGMS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Sphingomyelin Synthase 1 (SGMS1)
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别名
- SGMS1
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背景
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SGMS1 antibody detects Sphingomyelin synthase 1, encoded by the SGMS1 gene. Sphingomyelin synthase 1 is a plasma membrane-associated enzyme that catalyzes the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol. SGMS1 antibody provides researchers with a tool for studying sphingolipid metabolism, membrane biology, and signaling processes linked to cell survival and apoptosis.
Sphingomyelin synthase 1 belongs to the sphingomyelin synthase family of enzymes and is localized at the plasma membrane and Golgi apparatus. Research using SGMS1 antibody has shown that the enzyme regulates levels of sphingomyelin, a major structural component of membranes, while simultaneously producing diacylglycerol, a second messenger that activates protein kinase C. This dual metabolic and signaling role highlights SGMS1 as a central regulator of lipid homeostasis and cell signaling pathways.
Studies with SGMS1 antibody have demonstrated that disruption of SGMS1 alters plasma membrane composition, impairing lipid raft formation and receptor signaling. Deficiency in SGMS1 leads to accumulation of ceramide, which promotes apoptosis, while excess activity favors cell survival and proliferation. This balance underscores the importance of SGMS1 in processes ranging from development to disease.
Dysregulation of Sphingomyelin synthase 1 has been associated with cancer, metabolic disease, and immune dysfunction. Research using SGMS1 antibody has shown that high SGMS1 activity supports tumor cell survival, while inhibition sensitizes cells to apoptosis-inducing agents. In immune biology, SGMS1 influences T cell receptor signaling and cytokine release. These findings make SGMS1 both a biomarker and a potential therapeutic target.
SGMS1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in cell lines and tissues, immunohistochemistry demonstrates expression in tumors and metabolic tissues, and immunofluorescence highlights subcellular distribution. These approaches make SGMS1 antibody indispensable for lipid biology research.
By supplying validated SGMS1 antibody reagents, NSJ Bioreagents supports studies into sphingolipid metabolism, apoptosis, and disease. Detection of Sphingomyelin synthase 1 provides researchers with insight into how lipid enzymes regulate both membrane composition and signaling. -
UniProt
- Q86VZ5
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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