PUM1 抗体 (AA 1-361)
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北京 101111
Quick Overview for PUM1 抗体 (AA 1-361) (ABIN7869251)
抗原
See all PUM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-361
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原理
- PUM1 Antibody / Pumilio 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PUM1 recombinant protein (Position: M1-D361) was used as the immunogen for the PUM1 antibody.
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亚型
- IgG
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anti-Pumilio Homolog 1 (PUM1) antibody
PUM1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1070 unconjugated Recombinant Antibody
anti-Pumilio Homolog 1 (PUM1) (AA 62-91) antibodyPUM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB16264 unconjugated
anti-Pumilio Homolog 1 (PUM1) (AA 1-280) antibodyPUM1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Pumilio Homolog 1 (PUM1) (AA 1-130) antibodyPUM1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Pumilio Homolog 1 (PUM1) (AA 225-275) antibodyPUM1 适用: 人, 小鼠 WB, IP 宿主: 山羊 Polyclonal unconjugated
anti-Pumilio Homolog 1 (PUM1) antibodyPUM1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Pumilio Homolog 1 (PUM1) (AA 1-30), (N-Term) antibodyPUM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB10535 unconjugated
anti-Pumilio Homolog 1 (PUM1) (AA 201-300) antibodyPUM1 适用: 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pumilio Homolog 1 (PUM1) (AA 1-1186) antibodyPUM1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Pumilio Homolog 1 (PUM1) (Internal Region) antibodyPUM1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PUM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PUM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PUM1 (Pumilio Homolog 1 (PUM1))
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别名
- PUM1
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背景
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PUM1 antibody detects Pumilio homolog 1, encoded by the PUM1 gene. Pumilio homolog 1 is a highly conserved RNA binding protein that regulates post-transcriptional gene expression by controlling mRNA stability and translation. PUM1 antibody provides researchers with an essential reagent to study RNA biology, developmental regulation, and disease mechanisms involving RNA processing.
Pumilio homolog 1 belongs to the Pumilio and FBF family of proteins, which are characterized by their PUF RNA binding domains. Research using PUM1 antibody has shown that PUM1 binds to specific sequences in the 3' untranslated regions of target mRNAs, promoting degradation or translational repression. Through this activity, PUM1 regulates diverse biological processes, including cell proliferation, differentiation, and neuronal function.
Studies with PUM1 antibody have demonstrated that it participates in developmental pathways by regulating maternal mRNAs during embryogenesis. In germline cells, PUM1 contributes to stem cell maintenance by repressing differentiation-promoting transcripts. These findings underscore its importance in balancing self-renewal and differentiation in development.
Pumilio homolog 1 also influences neuronal biology. Research using PUM1 antibody has shown that it regulates synaptic function by controlling translation of synaptic mRNAs. Dysregulation of PUM1 is associated with neurological disorders, including intellectual disability and ataxia. Mutations that impair PUM1 function alter neuronal protein synthesis, contributing to disease pathology.
In cancer, PUM1 has been implicated in tumor progression. Studies with PUM1 antibody have revealed that altered expression modulates proliferation and survival pathways, supporting malignant growth. By controlling mRNA turnover of oncogenes and tumor suppressors, PUM1 integrates into signaling networks that determine tumor cell fate.
PUM1 antibody is widely used in western blotting, immunohistochemistry, and RNA immunoprecipitation. Western blotting quantifies protein expression, immunohistochemistry reveals localization in tissues such as brain and ovary, and RNA immunoprecipitation identifies bound target transcripts. These applications make PUM1 antibody indispensable for RNA biology research.
By providing validated PUM1 antibody reagents, NSJ Bioreagents supports studies into RNA regulation, development, and disease. Detection of Pumilio homolog 1 provides researchers with insight into how post-transcriptional control shapes cellular function. -
UniProt
- Q14671
抗原
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