DTNBP1 抗体 (AA 1-351)
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北京 101111
Quick Overview for DTNBP1 抗体 (AA 1-351) (ABIN7869237)
抗原
See all DTNBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-351
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原理
- DTNBP1 Antibody / Dysbindin
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Dysbindin/DTNBP1 recombinant protein (Position: M1-S351) was used as the immunogen for the DTNBP1 antibody.
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亚型
- IgG
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anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 258-351) antibody
DTNBP1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 179-319) antibodyDTNBP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 1-100) antibodyDTNBP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B4 unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (C-Term) antibodyDTNBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) antibodyDTNBP1 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 8-38), (N-Term) antibodyDTNBP1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB9243 unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 296-325), (C-Term) antibodyDTNBP1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB9241 unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 110-305) antibodyDTNBP1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) antibodyDTNBP1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dystrobrevin Binding Protein 1 (DTNBP1) (AA 101-200) antibodyDTNBP1 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the DTNBP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DTNBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
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别名
- DTNBP1
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背景
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DTNBP1 antibody detects Dystrobrevin-binding protein 1 (commonly known as Dysbindin), a cytoplasmic protein involved in vesicle trafficking, synaptic function, and organelle biogenesis. Encoded by the DTNBP1 gene on chromosome 6p22.3, this protein is a core component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Through its scaffolding and trafficking functions, Dysbindin regulates endosomal transport, melanosome formation, and neurotransmitter release, particularly within neuronal and pigment cells.
Dysbindin interacts with other BLOC-1 subunits, including SNAPIN, MUTED, and BLOC1S proteins, coordinating actin-based vesicular transport. In neurons, it contributes to synaptic vesicle recycling and glutamatergic signaling, influencing synaptic plasticity and cognitive processes. Dysbindin localizes to endosomes and synaptic vesicles, reflecting its role in membrane trafficking and receptor recycling.
The DTNBP1 antibody is widely used in neuroscience, cell biology, and genetic disease research to examine endosomal transport, synaptic vesicle dynamics, and intracellular trafficking. Western blot analysis identifies a 40 kilodalton band corresponding to Dysbindin, while immunofluorescence shows punctate cytoplasmic staining consistent with endosomal localization. This antibody supports investigations into molecular mechanisms of vesicle regulation and neurotransmission.
Loss-of-function mutations or reduced expression of DTNBP1 have been associated with Hermansky-Pudlak syndrome type 7 and susceptibility to schizophrenia, linking Dysbindin to synaptic homeostasis and neurodevelopment. Dysbindin also influences muscle membrane stability by binding to dystrobrevins. The DTNBP1 antibody provides a dependable reagent for exploring vesicle trafficking, neurological function, and genetic disorders. NSJ Bioreagents validates this antibody for its applications, ensuring reproducible detection in cellular and neurological research. -
UniProt
- Q96EV8
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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