Recombinant INSM1 抗体 (AA 1-300)
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Quick Overview for Recombinant INSM1 抗体 (AA 1-300) (ABIN7869128)
抗原
See all INSM1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-300
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原理
- INSM1 Antibody / IA1 / Insulinoma associated protein 1 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 1-300) from the human protein was used as the immunogen for the INSM1 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the INSM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the INSM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- INSM1 (Insulinoma-Associated 1 (INSM1))
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别名
- INSM1
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背景
- Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.
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UniProt
- Q01101
抗原
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