DUSP10 抗体 (AA 1-30)
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Quick Overview for DUSP10 抗体 (AA 1-30) (ABIN7869087)
抗原
See all DUSP10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-30
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原理
- Dual specificity protein phosphatase 10 Antibody / DUSP10
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纯化方法
- Purified
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免疫原
- A portion of amino acids 1-30 from the human protein was used as the immunogen for the Dual specificity protein phosphatase 10 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Dual specificity protein phosphatase 10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Dual specificity protein phosphatase 10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))
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别名
- Dual specificity protein phosphatase 10
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背景
- Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique, it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.
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UniProt
- Q9Y6W6
抗原
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