TOLLIP 抗体 (AA 1-274)
Our Local Distributor
北京 101111
Quick Overview for TOLLIP 抗体 (AA 1-274) (ABIN7869030)
抗原
See all TOLLIP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-274
-
原理
- Toll-interacting protein Antibody / TOLLIP
-
纯化方法
- Antigen affinity purified
-
免疫原
- E. coli-derived recombinant human protein (amino acids M1-P274) was used as the immunogen for the Toll-interacting protein antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the Toll-interacting protein antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the Toll-interacting protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- TOLLIP (Toll Interacting Protein (TOLLIP))
-
别名
- Toll-interacting protein
-
背景
- TOLLIP (TOLL-Interacting Protein) is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene. Lo et al.(2009) stated that the TOLLIP gene maps to chromosome 11. The mouse gene maps to chromosome 7. By western blot analysis of embryonic kidney cells, Burns et al.(2000) confirmed the binding of TOLLIP to IL1RAP, to a complex of IL1RAP-IL1R1, and to IL18R. Burns et al.(2000) proposed that IL1B stimulation induces aggregation of IL1Rs, recruitment of MYD88 followed by TOLLIP-IRAK complexes, and the phosphorylation of IRAK by MYD88. This leads to the dissociation of TOLLIP from IRAK, which can then transmit the IL1-induced signals.
-
UniProt
- Q9H0E2
抗原
-