TOLLIP 抗体 (C-Term)
(5 references)-
- 抗原 See all TOLLIP 抗体
- TOLLIP (Toll Interacting Protein (TOLLIP))
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抗原表位
- AA 221-250, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TOLLIP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This TOLLIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human TOLLIP.
- 克隆位点
- RB4409
- 亚型
- Ig Fraction
- Top Product
- Discover our top product TOLLIP Primary Antibody
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anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibody
TOLLIP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibodyTOLLIP 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A5-2A3 unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 19-254) antibodyTOLLIP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibodyTOLLIP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibodyTOLLIP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 61-274) antibodyTOLLIP 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal k1B17 unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 28-261) antibodyTOLLIP 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 86-163) antibodyTOLLIP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibodyTOLLIP 适用: 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal Kimmy-2 unconjugated
anti-Toll Interacting Protein (TOLLIP) antibodyTOLLIP 适用: 人, 小鼠 WB, IP 宿主: 大鼠 Monoclonal Kimmy-1 unconjugated
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- 应用备注
- WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Differential expression of novel tyrosine kinase substrates during breast cancer development." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 12, pp. 2072-87, (2007) (PubMed).
: "Negative regulation of toll-like receptor-mediated signaling by Tollip." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7059-65, (2002) (PubMed).
: "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 2, pp. 987-94, (2001) (PubMed).
: "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor." in: Nature cell biology, Vol. 2, Issue 6, pp. 346-51, (2000) (PubMed).
: "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex." in: FEBS letters, Vol. 419, Issue 1, pp. 41-4, (1998) (PubMed).
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: "Differential expression of novel tyrosine kinase substrates during breast cancer development." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 12, pp. 2072-87, (2007) (PubMed).
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- 抗原
- TOLLIP (Toll Interacting Protein (TOLLIP))
- 别名
- TOLLIP (TOLLIP 产品)
- 别名
- IL-1RAcPIP antibody, 4930403G24Rik antibody, 4931428G15Rik antibody, fk22a02 antibody, im:7145391 antibody, wu:fk22a02 antibody, zgc:76985 antibody, TOLLIP antibody, GB17961 antibody, tollip antibody, tollip1 antibody, tollipa antibody, TOLIP antibody, toll interacting protein antibody, toll-interacting protein antibody, toll-interacting protein-like antibody, toll interacting protein L homeolog antibody, toll interacting protein S homeolog antibody, Toll-interleukine I receptor interacting protein I antibody, TOLLIP antibody, Tollip antibody, tollip antibody, LOC552034 antibody, LOC100169858 antibody, tollip.L antibody, tollip.S antibody, LOC100136122 antibody
- 背景
- Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. TOLLIP also interacts with TLR2 and TLR4, TOLLIP overexpression inhibits nuclear factor kappa-B (NFKB) activation in response to lipopolysaccharide and IL1B.
- 分子量
- 30282
- NCBI登录号
- NP_061882
- UniProt
- Q9H0E2
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