NKX2-1 抗体 (AA 1-200)
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北京 101111
Quick Overview for NKX2-1 抗体 (AA 1-200) (ABIN7868682)
抗原
See all NKX2-1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- NKX2.1 Antibody / TTF-1 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment (within amino acids 1-200) of human TTF-1 protein was used as the immunogen for the NKX2.1 antibody.
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亚型
- IgG2a, kappa
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应用备注
- Optimal dilution of the NKX2.1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the NKX2.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
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别名
- NKX2.1
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背景
- Recognizes a protein of 40 kDa, identified as Homeobox protein Nkx-2.1, also called Thyroid transcription factor-1 (TTF-1). NKX2.1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-NKX2.1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. NKX2.1/TTF-1 reactivity is also seen in thyroid malignancies.
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UniProt
- P43699
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour
抗原
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