Recombinant MSH6 抗体 (AA 1-200)
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Quick Overview for Recombinant MSH6 抗体 (AA 1-200) (ABIN7868659)
抗原
See all MSH6 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- MSH6 Antibody / G/T mismatch-binding protein
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the MSH6 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the MSH6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MSH6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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别名
- MSH6
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背景
- MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. MSH6 expressed in all proliferating cells participate in repair of base-base mismatch, that occur during DNA replication. Loss of MSH6 expression leads to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of the genome with short repetitive nucleotide sequences, a phenomenon known as microsatellite instability (MSI). MSH6 always used as panel with MLH1, MSH2, PMS2, and may be useful to aid in identifying the most probable gene responsiblefor the MSI.
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UniProt
- P52701
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途径
- DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
抗原
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