PARK7/DJ1 抗体 (AA 1-189)
Our Local Distributor
北京 101111
Quick Overview for PARK7/DJ1 抗体 (AA 1-189) (ABIN7868327)
抗原
See all PARK7/DJ1 (PARK7) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-189
-
原理
- Zebrafish DJ-1 Antibody / PARK7
-
纯化方法
- Antigen affinity chromatography
-
免疫原
- An E.coli-derived zebrafish DJ-1/PARK7 recombinant protein (amino acids M1-D189) was used as the immunogen for the Zebrafish DJ-1 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Optimal dilution of the Zebrafish DJ-1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the Zebrafish DJ-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
-
别名
- DJ-1
-
背景
- Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.
-
UniProt
- Q5XJ36
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
抗原
-