ITGB3BP 抗体 (AA 1-177)
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Quick Overview for ITGB3BP 抗体 (AA 1-177) (ABIN7868260)
抗原
See all ITGB3BP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-177
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原理
- CENP-R Antibody / Centromere protein R / ITGB3BP
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived human recombinant protein (amino acids M1-N177) was used as the immunogen for the CENP-R antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the CENP-R antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CENP-R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
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别名
- CENP-R
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背景
- Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
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UniProt
- Q13352
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途径
- Neurotrophin Signaling Pathway
抗原
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