NANOS3 抗体 (AA 1-159)
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Quick Overview for NANOS3 抗体 (AA 1-159) (ABIN7868223)
抗原
See all NANOS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-159
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原理
- Zebrafish Nanos3 Antibody / Nanos homolog 3
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Nanos3 recombinant protein (amino acids M1-W159) was used as the immunogen for the Zebrafish Nanos3 antibody.
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亚型
- Ig Fraction
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anti-Nanos Homolog 3 (NANOS3) (AA 1-100) antibody
NANOS3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B11 unconjugated
anti-Nanos Homolog 3 (NANOS3) (AA 21-192) antibodyNANOS3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nanos Homolog 3 (NANOS3) (AA 101-173) antibodyNANOS3 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nanos Homolog 3 (NANOS3) (C-Term) antibodyNANOS3 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Nanos3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Nanos3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NANOS3 (Nanos Homolog 3 (NANOS3))
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别名
- Nanos3
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背景
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Nanos3 is a highly conserved RNA binding protein that plays an essential role in the development and maintenance of germ cells. In zebrafish, Nanos3 is required for the proper specification, migration, and survival of primordial germ cells during early embryogenesis.
Zebrafish Nanos3 is an ortholog of the human NANOS3 gene. Both genes belong to the Nanos family of translational repressors and share conserved structural features, including zinc finger domains that enable binding to target messenger RNAs. Nanos3 acts primarily by interacting with other RNA binding proteins to repress the translation of specific transcripts involved in cell differentiation and apoptosis.
In zebrafish embryos, Nanos3 is expressed maternally and zygotically in germ cell precursors. It ensures the correct localization and survival of these cells as they migrate toward the developing gonads. Loss of Nanos3 function in zebrafish leads to the mislocalization and eventual loss of germ cells, resulting in infertility or defective gonadal development.
Because of its conserved role in germline development, zebrafish Nanos3 serves as a valuable marker for early germ cells and is widely used in studies of reproductive biology, stem cell maintenance, and gene regulation. It is also a useful model for understanding human infertility and germ cell tumors.
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UniProt
- Q90WW1
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途径
- ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Response to Molecule of Bacterial Origin, Myometrial Relaxation and Contraction, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling
抗原
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