Recombinant PMS2 抗体 (AA 1-100)
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Quick Overview for Recombinant PMS2 抗体 (AA 1-100) (ABIN7867882)
抗原
See all PMS2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-100
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原理
- Recombinant PMS2 Antibody / PMS1 homolog 2
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纯化方法
- Protein A affinity chromatography
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免疫原
- A portion of amino acids 1-100 from the human protein was used as the immunogen for the recombinant PMS2 antibody.
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亚型
- IgG
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anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 748-851) antibody
PMS2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1E9D11 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 748-851) antibodyPMS2 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8E4G11 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) antibodyPMS2 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6G12E1 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 748-851) antibodyPMS2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6A12H9 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) antibodyKO Validated PMS2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 25GB3205 unconjugated Recombinant Antibody
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 1-862) antibodyPMS2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 763-862) antibodyPMS2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4D11 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 390-670) antibodyPMS2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 1-862) antibodyPMS2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 763-862) antibodyPMS2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4A8 unconjugated
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应用备注
- Optimal dilution of the recombinant PMS2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant PMS2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
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别名
- PMS2
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背景
- PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15 % of all colon cancers. Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS), also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.
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UniProt
- P54278
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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