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Recombinant TdT 抗体 (AA 1-100)

The 兔 单克隆 anti-TdT antibody is suitable to detect TdT in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7867842
发货至: 中国
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Quick Overview for Recombinant TdT 抗体 (AA 1-100) (ABIN7867842)

抗原

See all TdT (DNTT) 抗体
TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

抗体类型

Recombinant Antibody

适用

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宿主

  • 88
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克隆类型

  • 63
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  • 1
单克隆

标记

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This TdT antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

DNTT-4506R
  • 抗原表位

    • 14
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    AA 1-100

    原理

    DNA nucleotidylexotransferase Antibody / TdT

    纯化方法

    Protein A/G affinity

    免疫原

    A portion of amino acids 1-100 from the human protein was used as the immunogen for the DNA nucleotidylexotransferase antibody.

    亚型

    IgG, kappa
  • 应用备注

    Optimal dilution of the DNA nucleotidylexotransferase antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the DNA nucleotidylexotransferase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

    别名

    DNA nucleotidylexotransferase

    背景

    Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

    UniProt

    P04053

    途径

    DNA Damage Repair
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