Recombinant FLT3 抗体 (PE)
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北京 101111
Quick Overview for Recombinant FLT3 抗体 (PE) (ABIN7867268)
抗原
See all FLT3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PE-conjugated Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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亚型
- IgG1
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应用备注
- Flow Cyt 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid PBS with 0.05 % Proclin300, 1 % BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2°C-8°C for 6 months
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有效期
- 6 months
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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别名
- FLT3
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背景
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Synonyms: Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3
Target Background: Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
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UniProt
- P36888
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途径
- RTK signaling
抗原
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