Recombinant TPO 抗体
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北京 101111
Quick Overview for Recombinant TPO 抗体 (ABIN7862182)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody
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特异性
- Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. 79oΩMalignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human TPO (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-TPO (Internal Region) antibody
适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TPO antibody适用: 人 IHC 宿主: 兔 Monoclonal unconjugated
anti-TPO (AA 685-804) antibody适用: 人 IHC 宿主: 小鼠 Monoclonal TPO-1921 unconjugated
anti-TPO (AA 685-804) antibody适用: 人 IHC 宿主: 兔 Monoclonal TPO-3813R unconjugated Recombinant Antibody
anti-TPO (AA 19-846) antibody适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- TPO
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背景
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MSA, TDH2A, Thyroid microsomal antigen, Thyroid peroxidase, Thyroperoxidase, TPO, TPX
Human thyroid carcinoma.
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分子量
- 100kDa
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基因ID
- 7173, 467554
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UniProt
- P07202
抗原
-
