Recombinant ROR gamma 抗体
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Quick Overview for Recombinant ROR gamma 抗体 (ABIN7864186)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant ROR-gamma / RORC (RAR-related Orphan Receptor C) Antibody
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特异性
- Retina-associated orphan receptors (RORs) contains three subtypes: ROR±, ROR≤, and RORé 79oΩ. They are widely distributed in body tissues, and most of them can directly enter the nucleus to regulate the transcription of target genes, thus showing different tissue specificity and participating in different physiological processes. In particular, ROR± and RORé 79oΩ play an important role in mediating Th17 cell differentiation. RORé 79oΩ can be divided into RORé 79oΩ1 and RORé 79oΩ2 (RORé 79oΩ T), which show different tissue specificity. ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ double positive thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTi) cells of lymphoid organs. At present, RORé 79oΩ T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORé 79oΩ T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human ROR gamma T protein
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亚型
- IgG, kappa
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anti-ROR gamma (Internal Region) antibody
适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma (Center) antibody适用: 人, 小鼠, Cow, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma antibody适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- ROR gamma
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别名
- ROR-gamma
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背景
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Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR
Human pancreas|liver or skeletal muscle tissue.
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分子量
- 55kDa
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基因ID
- 6097
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UniProt
- P51449-2
抗原
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