ROR gamma 抗体
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北京 101111
Quick Overview for ROR gamma 抗体 (ABIN7863353)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ROR-gamma / RORC (RAR-related Orphan Receptor C) Antibody
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特异性
- This MAb recognizes a protein of 63 kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR°™ and RORÁ are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50 % amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors, due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human RORC protein
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亚型
- IgG2a, kappa
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anti-ROR gamma (Internal Region) antibody
适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma (Center) antibody适用: 人, 小鼠, Cow, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma antibody适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- ROR gamma
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别名
- ROR-gamma
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背景
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Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR
MOLT4 cells. Human lymphocytes. Human liver or skeletal muscle tissue.
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分子量
- 63kDa
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基因ID
- 6097
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UniProt
- P51449
抗原
-
