POU1F1 抗体
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北京 101111
Quick Overview for POU1F1 抗体 (ABIN7863259)
抗原
See all POU1F1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- POU1F1 / PIT-1 Antibody
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特异性
- Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant human full-length POU1F1 protein
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亚型
- IgG2b, kappa
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anti-POU Class 1 Homeobox 1 (POU1F1) (C-Term) antibody
POU1F1 适用: 人, 小鼠, 大鼠, 犬, Cow, 山羊, 马, 兔, 绵羊, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-POU Class 1 Homeobox 1 (POU1F1) antibodyPOU1F1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-POU Class 1 Homeobox 1 (POU1F1) (C-Term) antibodyPOU1F1 适用: 人, 小鼠, 大鼠, 犬, Cow, 山羊, 马, 兔, 绵羊, 豚鼠, Pig, 斑马鱼, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-POU Class 1 Homeobox 1 (POU1F1) (AA 75-124) antibodyPOU1F1 适用: 人, 小鼠, 大鼠, 犬, Cow, 山羊, 马, 兔, 绵羊, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-POU Class 1 Homeobox 1 (POU1F1) (N-Term) antibodyPOU1F1 适用: 人, 小鼠, 大鼠, 犬, Cow, 山羊, 马, 兔, 绵羊, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-POU Class 1 Homeobox 1 (POU1F1) (N-Term) antibodyPOU1F1 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-POU Class 1 Homeobox 1 (POU1F1) antibodyPOU1F1 适用: 人, 犬 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- POU1F1 (POU Class 1 Homeobox 1 (POU1F1))
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别名
- POU1F1
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背景
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Dwarf, GHF1A, Growth hormone factor 1, Hmp1, PiT-1, Pit1 beta, PIT1Z, Pituitary growth hormone, Pituitary specific positive transcription factor 1, POU domain class 1 transcription factor 1, POU domain transcriptional regulator, POU1F1
Human pituitary or tonsil.
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分子量
- 31-35kDa
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基因ID
- 5449, 591654
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UniProt
- P28069
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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