HDAC6 抗体 (pSer22) (Cy3)
Quick Overview for HDAC6 抗体 (pSer22) (Cy3) (ABIN742991)
抗原
See all HDAC6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer22
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human HDAC6 around the phosphorylation site of Ser22
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- HDAC6 (Histone Deacetylase 6 (HDAC6))
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别名
- HDAC6
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背景
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Synonyms: HDAC6 phospho S22, HDAC6 phospho Ser22, p-HDAC6 Ser22, HD 6, HD6, HDAC 6, Histone deacetylase 6, HD6, Histone deacetylase 6, JM 21, JM21, KIAA0901, FLJ16239, HDAC6_HUMAN.
Background: HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.
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基因ID
- 10013
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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