HES5 抗体
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北京 101111
Quick Overview for HES5 抗体 (ABIN7865264)
抗原
See all HES5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HES5 / bHLHb38 / Hes family bHLH transcription factor 5 Antibody
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特异性
- The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human HES5 protein (exact sequence is proprietary)
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亚型
- IgG2, kappa
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anti-Hairy and Enhancer of Split 5 (HES5) antibody
HES5 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 21-120) antibodyHES5 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 1-50) antibodyHES5 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 83-95) antibodyHES5 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴 WB, ELISA, IHC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 81-115) antibodyHES5 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51477 unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 28-121) antibodyHES5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 28-121) antibodyHES5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (AA 1-166) antibodyHES5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) (C-Term) antibodyHES5 适用: 人, 小鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Hairy and Enhancer of Split 5 (HES5) antibodyHES5 适用: 人 WB 宿主: 兔 Monoclonal 23GB6360 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- HES5 (Hairy and Enhancer of Split 5 (HES5))
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别名
- HES5
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背景
- BHLHb38
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分子量
- 41kDa
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基因ID
- 388585, 57971
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UniProt
- Q5TA89
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途径
- Stem Cell Maintenance, Tube Formation
抗原
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