Recombinant Complement C4d 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant Complement C4d 抗体 (ABIN7863829)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Recombinant Complement 4d (C4d) (Acute Humoral Rejection Marker) Antibody
-
特异性
- This MAb is specific to Complement 4d (C4d) and reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
-
纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
-
免疫原
- Recombinant full-length human Complement 4d protein
-
亚型
- IgG, kappa
-
-
anti-Complement Component C4d (C4d) (Internal Region) antibody
C4d 适用: 人 IHC (p) 宿主: 兔 Monoclonal A24-T unconjugated
anti-Complement Component C4d (C4d) antibodyC4d 适用: 人 ELISA, IF, Coat, IHC (f) 宿主: 小鼠 Monoclonal C4D204 unconjugated
anti-Complement Component C4d (C4d) (AA 958-1335) antibodyC4d 适用: 人 IHC, WB, IP, ICC 宿主: 小鼠 Monoclonal D2 unconjugated
anti-Complement Component C4d (C4d) (AA 958-1335) antibodyC4d 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C4d (C4d) (AA 1241-1256) antibodyC4d 适用: 人 IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C4d (C4d) antibodyCarrier-free C4d 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal C4D204 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
-
- Complement C4d (C4d) (Complement Component C4d (C4d))
-
别名
- Complement 4d
-
背景
-
Acidic Complement C4, Basic C4, C4-1, C4a Anaphylatoxin, C4A, C4A2, C4A3, C4A4, C4A6, C4b, C4B1, C4B12, C4d fragment, C4F, C4S, Complement C4 Gamma Chain, Complement Component 4A, Complement Component 4B
Rejected Renal Transplant Tissue
-
分子量
- 192kDa (predicted)
-
基因ID
- 720, 721
-
UniProt
- P0C0L4, P0C0L5
抗原
-
