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Complement C4d 抗体

C4d 适用: 人 IHC (fro), WB, IA 宿主: 小鼠 Monoclonal 12D11 unconjugated
产品编号 ABIN2192222
发货至: 中国
  • 抗原 See all Complement C4d (C4d) products
    Complement C4d (C4d) (Complement Component C4d (C4d))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Complement C4d antibody is un-conjugated
    应用范围
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    Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Immunoassay (IA)
    过滤
    0.2 μm filtered
    克隆位点
    12D11
  • 应用备注
    It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • Zwirner, Felber, Burger, Bitter-Suermann, Riethmüller, Feucht: "Classical pathway of complement activation in mammalian kidneys." in: Immunology, Vol. 80, Issue 2, pp. 162-7, (1994) (PubMed).

    Feucht, Schneeberger, Hillebrand, Burkhardt, Weiss, Riethmüller, Land, Albert: "Capillary deposition of C4d complement fragment and early renal graft loss." in: Kidney international, Vol. 43, Issue 6, pp. 1333-8, (1993) (PubMed).

  • 抗原
    Complement C4d (C4d) (Complement Component C4d (C4d))
    别名
    c4d (C4d 产品)
    背景
    Chain of human C4d. Complement factor C4 (MW 41 kDa), formerly known as Gg protein, consists of an alpha-, beta- and gamma-chain. The classical pathway of complement and the mannose binding lectin (MBL) activation pathway converge at C4. Activated C1, MASP-1 and MASP-2 cleave C4 resulting in the formation of C4a and C4b. The latter can be cleaved by factor I resulting in C4c and C4d, in which step all functional sites are lost. The C4d activation fragment of C4 is an excellent marker for classical complement pathway and MBL pathway activation. The thioester formed between the side chains of Cys1010 and Gln1013 within the C4d region of the α-chain mediates covalent attachment to the target surface bearing activated forms of C1s or MASP. Furthermore, C4d is highly homologous to C3d with over 35 % shared amino acid sequence. In a number of diseases such as rheumatoid arthritis (RA), hereditary angioedema (HAE), systemic lupus erythematosus (SLE) and chronic urticaria with hypercomplementemia levels of C4d are significantly elevated in serum or plasma. C4d levels may also be elevated in plasma from patients with a variety of humoral autoimmune diseases in which complement activation is known to occur. Deposition of C4d in peritubular capillaries has been shown to be a sensitive marker for antibody-mediated (humoral) rejection in renal transplant biopsies. The monoclonal antibody 12D11 recognizes C4, C4b and C4d. Antibody 12D11 cross reacts with pig, bovine, baboon and rhesus monkey. Mouse IgG1
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