CPS1 抗体
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北京 101111
Quick Overview for CPS1 抗体 (ABIN7860965)
抗原
See all CPS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody
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特异性
- This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. 79oΩDeficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human CPS1 protein (exact sequence is proprietary)
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亚型
- IgG
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anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) antibody
KD Validated CPS1 适用: 人 WB, ICC, IF (p), FACS 宿主: 兔 Monoclonal 23GB2365 unconjugated Recombinant Antibody
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1400-1500) antibodyCPS1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 8H8 unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1361-1500) antibodyCPS1 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 124-379) antibodyCPS1 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (Middle Region) antibodyCPS1 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, Cow, 兔, 马, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (N-Term) antibodyCPS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) antibodyCPS1 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 1400-1501) antibodyCPS1 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 8H8 unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 151-200) antibodyCPS1 适用: 人, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1) (AA 951-1000) antibodyCPS1 适用: 人, 大鼠, 小鼠, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
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别名
- CPS1
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背景
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Carbamoyl-phosphate synthetase 1 (CPS1), Carbamoylphosphate synthetase 1, CPSase 1, CPSASE1
Human liver or hepatocellular carcinoma (HCC).
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分子量
- ~165kDa
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基因ID
- 1373, 149252
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UniProt
- P31327
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途径
- Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
抗原
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