MCM4 抗体 (AA 600-800)
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北京 101111
Quick Overview for MCM4 抗体 (AA 600-800) (ABIN7865407)
抗原
See all MCM4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 600-800
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原理
- MCM4 (Pan Cancer Marker) Antibody
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特异性
- The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double- stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity, and MCM5 is involved in IFN-≥-induced Stat1± transcription activation.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa600-800) of human MCM4 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 1-863) antibody
MCM4 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 1-863) antibodyMCM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 2-141) antibodyMCM4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 750-800) antibodyMCM4 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 325-375) antibodyMCM4 适用: 人 IHC 宿主: 山羊 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 325-375) antibodyMCM4 适用: 人, 小鼠 WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 750-800) antibodyMCM4 适用: 人, 小鼠 WB, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4960 unconjugated Recombinant Antibody
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2495 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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别名
- MCM4
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背景
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NKCD, CDC21, CDC54, IMD54, NKGCD, hCdc21, P1-CDC21
A-431 cells. Human colon.
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分子量
- 100kDa
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基因ID
- 4173, 460184
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UniProt
- P33991
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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