CD33 抗体 (AA 51-224)
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Quick Overview for CD33 抗体 (AA 51-224) (ABIN7863634)
抗原
See all CD33 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 51-224
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原理
- CD33 / SIGLEC3 (Myeloid Cell Surface Antigen) Antibody
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特异性
- Recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa51-224) of human CD33 protein (exact sequence is proprietary)
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亚型
- IgG2c, kappa
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anti-CD33 (CD33) (AA 101-200) antibody
CD33 适用: 人, 小鼠 FACS, WB, ELISA, IHC (fro), ICC, IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD33 (CD33) (AA 15-237) antibodyCD33 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 2C6B7 unconjugated
anti-CD33 (CD33) (AA 15-237) antibodyCD33 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 2C6B7 unconjugated
anti-CD33 (CD33) (AA 18-240) antibodyCD33 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD33 (CD33) (AA 49-259) antibodyCD33 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD33 (CD33) (AA 261-364) antibodyCD33 适用: 人 FACS, WB, ELISA, IHC (fro), IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD33 (CD33) (AA 1-364) antibodyCD33 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2D12-G4 unconjugated
anti-CD33 (CD33) (AA 18-259) antibodyCD33 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD33 (CD33) antibodyCD33 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD33 (CD33) (AA 18-269) antibodyCD33 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM77 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- CD33
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别名
- CD33
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背景
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gp67, My9, Myeloid cell surface antigen CD33, p67, Sialic acid-binding Ig-like lectin 3 (SIGLEC3)
Human dendritic and mast cells. Human lymph nodes and tonsils.
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分子量
- ~67kDa
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基因ID
- 945, 83731
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UniProt
- P20138
抗原
-
