RHOBTB2 抗体 (AA 500-700)
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北京 101111
Quick Overview for RHOBTB2 抗体 (AA 500-700) (ABIN7860332)
抗原
See all RHOBTB2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 500-700
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原理
- DBC2 / RHOBTB2 (Tumor Suppressor) Antibody
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特异性
- The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Human recombinant RHOBTB2 protein fragment (around aa500-700) (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 631-727) antibody
RHOBTB2 适用: 人 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 510-619) antibodyRHOBTB2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 1-727) antibodyRHOBTB2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 61-110) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (N-Term) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))
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别名
- DBC2
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背景
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Deleted in breast cancer 2 gene protein, p83, Rho related BTB domain containing protein 2
Human heart muscle or brain tissue.
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分子量
- 83kDa
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基因ID
- 23221, 372688
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UniProt
- Q9BYZ6
抗原
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