Recombinant P-Glycoprotein 抗体 (AA 500-700)
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Quick Overview for Recombinant P-Glycoprotein 抗体 (AA 500-700) (ABIN7860327)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 500-700
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原理
- Recombinant P-glycoprotein / p170 / MDR1 / CD243 Antibody
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特异性
- Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa500-700) of human ABCB1 protein (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-P-Glycoprotein (AA 647-677) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P-Glycoprotein antibody适用: 人, Hamster WB, IHC, FACS, ICC 宿主: 小鼠 Monoclonal JSB-1 unconjugated
anti-P-Glycoprotein antibody适用: 人, Hamster WB, IHC, FACS 宿主: 小鼠 Monoclonal JSB-1 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- P-Glycoprotein
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背景
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ABC20, ABCB1, ATP-binding cassette sub-family B member 1, CD243, CLCS, Colchicin sensitivity, Doxorubicin resistance, GP170, Multidrug resistance protein 1 (MDR1), P-glycoprotein 1 (PGY1)
hPBL or Jurkat whole cell lysate. Human adrenal gland.
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分子量
- 170kDa
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基因ID
- 5243, 489033
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UniProt
- P08183
抗原
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