MR1 抗体 (AA 50-250)
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北京 101111
Quick Overview for MR1 抗体 (AA 50-250) (ABIN7860265)
抗原
See all MR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 50-250
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原理
- MR1 / Major histocompatibility complex, class I-related Antibody
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特异性
- MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa50-250) of human MR1 protein (exact sequence is proprietary)
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亚型
- IgG2, kappa
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anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 201-300) antibody
MR1 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 312-341), (C-Term) antibodyMR1 适用: 人 WB 宿主: 兔 Polyclonal RB37199 unconjugated
anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 150-253) antibodyMR1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 20-260) antibodyMR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 150-253) antibodyMR1 适用: 人, 小鼠 ELISA, WB, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 20-260) antibodyMR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I-Related (MR1) (AA 201-300) antibodyMR1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- MR1 (Major Histocompatibility Complex, Class I-Related (MR1))
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别名
- MR1
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背景
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Class I histocompatibility antigen like protein, HLALS, Major histocompatibility complex class I like sequence, Major histocompatibility complex class I related isoform CRA a, MHC class I related gene protein, MHC class I related protein 1 isoform B, MR1B, MR1C
Human kidney|placenta or tonsil.
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分子量
- 39kDa
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基因ID
- 3140, 13500
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UniProt
- Q95460
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
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