Recombinant PAPPA 抗体 (AA 351-523)
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Quick Overview for Recombinant PAPPA 抗体 (AA 351-523) (ABIN7860004)
抗原
See all PAPPA 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 351-523
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原理
- Recombinant PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Antibody
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特异性
- Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 351-523) antibody
PAPPA 适用: 人 IHC 宿主: 小鼠 Monoclonal PAPPA-2715 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1321-1460) antibodyPAPPA 适用: 人, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 351-523) antibodyPAPPA 适用: 人 IHC 宿主: 小鼠 Monoclonal 780M unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 999-1272) antibodyPAPPA 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 317-532) antibodyPAPPA 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 95-302) antibodyPAPPA 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 IHC, WB, IP, ICC 宿主: 小鼠 Monoclonal H4 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 85-194) antibodyPAPPA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 95-388) antibodyPAPPA 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 IHC, WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
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别名
- PAPP-A
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背景
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ASBABP2, Aspecific BCL2 ARE binding protein 2, Differentially placenta 1 expressed protein, DIPLA1, IGF-dependent, IGFBP4ase, Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease), PAPA, PAPP A, PAPPA1, Pappalysin-1, Pregnancy Associated Plasma Protein A (PAPP-A)
Human placenta tissue.
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分子量
- 181kDa
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基因ID
- 5069, 643599
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UniProt
- Q13219
抗原
-
