IL-7 抗体 (AA 27-177)
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Quick Overview for IL-7 抗体 (AA 27-177) (ABIN7863016)
抗原
See all IL-7 (IL7) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 27-177
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原理
- Interleukin-7 (IL-7) Antibody
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特异性
- Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor Á chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 27-177) corresponding to mature protein of human IL7(exact sequence is proprietary)
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亚型
- IgG1, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- IL-7 (IL7) (Interleukin 7 (IL7))
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别名
- Interleukin-7
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背景
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IL 7, IL-7, Il7, Interleukin 7, Interleukin-7, LP-1, Lymphopoietin 1
Human thymus or tonsil tissue.
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分子量
- 25kDa
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基因ID
- 3574, 591873
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途径
- JAK/STAT Signaling
抗原
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