APOH 抗体 (AA 145-345)
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Quick Overview for APOH 抗体 (AA 145-345) (ABIN7859129)
抗原
See all APOH 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 145-345
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原理
- Apolipoprotein H / APOH Antibody
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特异性
- Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa145-345) of human APOH protein (exact sequence is proprietary)
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亚型
- IgG2c, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))
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别名
- Apolipoprotein H
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背景
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Activated protein C-binding protein, Anticardiolipin cofactor, APC inhibitor, Apo-H, apolipoprotein H (beta-2-glycoprotein I), B2G1, B2GP1, B2GPI, Beta 2 glycoprotein I precursor, Beta(2)GPI, BG, Glycoprotein 1, beta-2,
Human liver.
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分子量
- 38kDa
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基因ID
- 350, 445358
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UniProt
- P02749
抗原
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