CD276 抗体 (AA 100-300)
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北京 101111
Quick Overview for CD276 抗体 (AA 100-300) (ABIN7863528)
抗原
See all CD276 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-300
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原理
- CD276 / B7-H3 Antibody
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特异性
- T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa100-300) of human CD276 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-CD276 (CD276) (AA 47-219) antibody
CD276 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-CD276 (CD276) (C-Term) antibodyCD276 适用: 人, 小鼠 WB, IHC, FACS, IP, ICC, IF (p) 宿主: 兔 Monoclonal BLR025F unconjugated Recombinant Antibody
anti-CD276 (CD276) (AA 29-466) antibodyCD276 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8C1C2 unconjugated
anti-CD276 (CD276) (AA 493-522), (C-Term) antibodyCD276 适用: 人 WB, FACS, IHC (p), IF 宿主: 兔 Polyclonal RB31111 unconjugated
anti-CD276 (CD276) (AA 47-213) antibodyCD276 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD276 (CD276) (AA 29-465) antibodyCD276 适用: 人 WB, IHC, FACS, IP, ICC 宿主: 兔 Monoclonal BLR026F unconjugated Recombinant Antibody
anti-CD276 (CD276) (AA 29-458) antibodyCD276 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-CD276 (CD276) (AA 237-358) antibodyCD276 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E12 unconjugated
anti-CD276 (CD276) (AA 100-200) antibodyCD276 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD276 (CD276) antibodyKD Validated CD276 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB5035 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- CD276
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别名
- CD276
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背景
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4Ig B7 H3, B7 homolog 3, B7-H3, B7H3, B7RP-2, CD276, CD276 antigen, CD276 Molecule, Costimulatory molecule
hepatocellular carcinoma or lung carcinoma., Human tonsil, Placenta
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分子量
- B7-H3 isoforms: 57/34/53/57 kDa, glycosylated B7-H3: 90-110 kDa
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基因ID
- 80381, 77873
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UniProt
- Q5ZPR3
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途径
- Cancer Immune Checkpoints
抗原
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