T-Bet 抗体 (AA 1-200)
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Quick Overview for T-Bet 抗体 (AA 1-200) (ABIN7864466)
抗原
See all T-Bet 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- T-bet / Tbox-bet / TBX21 Antibody
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特异性
- T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine, IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 1-200) of human TBX21 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-T-Bet (AA 241-493) antibody
适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-T-Bet (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-T-Bet (AA 485-535) antibody适用: 人 WB, IHC, IP, FACS, ICC 宿主: 兔 Monoclonal BLR110H unconjugated Recombinant Antibody
anti-T-Bet (AA 338-387) antibody适用: 人, 大鼠, Cow, 犬, Pig, 兔, 豚鼠, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-T-Bet (Middle Region) antibody适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-T-Bet antibody适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-T-Bet (AA 160-399) antibody适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-T-Bet (AA 400-535) antibody适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F10 unconjugated
anti-T-Bet (AA 387-486) antibody适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F8 unconjugated
anti-T-Bet (AA 326-535) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- T-Bet
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背景
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T box expressed in T cells, T box protein 21, T box transcription factor TBX21, T cell specific T box transcription factor T bet, T PET, T-cell-specific T-box transcription factor T-bet, TBET, TBLYM, TPET, Transcription factor TBLYM
Human tonsil|non-Hodgkin s lymphoma or spleen. T-cell specific.
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分子量
- 62kDa
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基因ID
- 30009, 272409
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UniProt
- Q9UL17
抗原
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