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IRF3 抗体 (pSer396)

Name: IRF3 抗体 (pSer396)
SKU: ABIN742688
Availability: OutOfStock

There are 5+ publications for this product available. The 兔多克隆 anti-IRF3 antibody is suitable to detect IRF3 in samples from 人, 小鼠, 大鼠和猴. It has been validated for WB, ELISA, ICC, IHC (p), IF (cc), IF (p) 和 IHC (fro).

Mouse liver lysates probed with Anti-IRF3 (Ser396) Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C. (IRF3 抗体 (pSer396))

Formalin-fixed and paraffin embedded mouse stomach tissue labeled with Anti-Phospho-IRF3 (Ser396) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (IRF3 抗体 (pSer396))

IHC (p)

U251 lysates probed with IRF3 (Ser396) Polyclonal Antibody, unconjugated at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 60 minutes at 37°C. (IRF3 抗体 (pSer396))

Formalin-fixed and paraffin embedded mouse stomach tissue labeled with Anti-Phospho-IRF3 (Ser396) Polyclonal Antibody, Unconjugated (ABIN742688) at 1:200 followed by conjugation to the secondary antibody and DAB staining (IRF3 抗体 (pSer396))

IHC

Formalin-fixed and paraffin-embedded rat colitis labeled with Anti-Phospho-IRF3 (Ser396) Polyclonal Antibody, Unconjugated (ABIN742688) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. (IRF3 抗体 (pSer396))

5 images

(5 references)

产品编号 ABIN742688

发货至: 中国

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中国
北京 101111

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Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for IRF3 抗体 (pSer396) (ABIN742688)

抗原

See all IRF3 抗体

IRF3 (Interferon Regulatory Factor 3 (IRF3))

适用

人, 小鼠, 大鼠, 猴

宿主

兔

克隆类型

多克隆

标记

This IRF3 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

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pSer396

交叉反应

人, 猴, 小鼠, 大鼠

预测反应

Dog,Cow,Sheep,Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396

亚型

IgG
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibody
IRF3 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3C8 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibody
IRF3 适用: 人, 小鼠, 大鼠, 猴, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibody
IRF3 适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibody
IRF3 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (C-Term) antibody
IRF3 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) antibody
IRF3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 4C3 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) antibody
IRF3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer385) antibody
IRF3 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Korangath, Jin, Yang, Healy, Guo, Ke, Grüttner, Hu, Gabrielson, Foote, Clarke, Ivkov: "Iron Oxide Nanoparticles Inhibit Tumor Progression and Suppress Lung Metastases in Mouse Models of Breast Cancer." in: ACS nano, Vol. 18, Issue 15, pp. 10509-10526, (2024) (PubMed).

Ando, Matsumoto, Taguchi, Kobayashi: "Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries." in: Free radical biology & medicine, Vol. 112, pp. 553-566, (2017) (PubMed).

Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, (2015) (PubMed).

Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: "TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 4977-88, (2014) (PubMed).

Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." in: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, (2013) (PubMed).
抗原

IRF3 (Interferon Regulatory Factor 3 (IRF3))

别名

IRF3

背景

Synonyms: Interferon regulatory factor 3, IRF-3, IRF3
Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

基因ID

3661

UniProt

Q14653

途径

TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades