Cofilin 2 抗体 (AA 1-166)
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Quick Overview for Cofilin 2 抗体 (AA 1-166) (ABIN7865261)
抗原
See all Cofilin 2 (CFL2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-166
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原理
- CFL2 / NEM7 Antibody
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特异性
- Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-166) of human CFL2 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- Cofilin 2 (CFL2)
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别名
- CFL2
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背景
- NEM7
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分子量
- 19-21kDa
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基因ID
- 1073, 180141
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UniProt
- Q9Y281
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途径
- Caspase Cascade in Apoptosis
抗原
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