Recombinant CD39 抗体
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北京 101111
Quick Overview for Recombinant CD39 抗体 (ABIN7857782)
抗原
See all CD39 (ENTPD1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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Expression System
- CHO Cells
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原理
- Recombinant CD39 / ENTPD1 (Marker of Tumor-specific T cells) Antibody
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特异性
- CD39 is a transmembrane glycoprotein and an extracellular nucleotide-hydrolyzing enzyme that plays a key role in regulating extracellular ATP and ADP levels. Also known as E-type apyrase, CD39 hydrolyzes ATP and ADP to AMP, which is further converted to adenosine. By degrading ADP, CD39 inhibits platelet aggregation, contributing to its anti-thrombotic function and potential use in preventing coronary artery occlusion and thrombotic stroke. Intracellularly, CD39 undergoes glycosylation at six N-glycosylation sites before translocating to the membrane to become an active enzyme. Alternative splicing gives rise to three isoforms: vascular, placenta I, and placenta II, with variations at the N-terminus and C-terminus. CD39 is expressed in vascular tissues, including the placenta, lung, skeletal muscle, and kidney, as well as on endothelial cells, smooth muscle cells, cardiac cells, and platelets. In the immune system, CD39 is present on activated B cells, a subset of activated T cells, activated NK cells, macrophages, dendritic cells, and Langerhans cells. It is not expressed on resting lymphocytes but is found in lymphoid tissues, particularly in the mantle zone and paracortical lymphocytes. CD39-expressing cells may provide protection to lymphocytes from the toxic effects of ATP released from damaged cells. Originally identified on Epstein-Barr virus-transformed B cells, CD39 is now recognized as a key immunoregulatory enzyme involved in inflammation, immune suppression, and thrombotic balance.
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纯化方法
- 200ug/ml of Ab produced in CHO cell mammalian-based expression system.
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免疫原
- Prokaryotic recombinant protein corresponding to a portion of the external domain of the CD39 molecule
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亚型
- IgG2a, kappa
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anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 1-180) antibody
ENTPD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 300-350) antibodyENTPD1 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR285L unconjugated Recombinant Antibody
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 38-179) antibodyENTPD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8E9F2 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 38-179) antibodyENTPD1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6H12F9 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibodyENTPD1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 241-486) antibodyENTPD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 316-474) antibodyENTPD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 398-411), (Extracellular) antibodyENTPD1 适用: 人 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibodyENTPD1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibody (FITC)ENTPD1 适用: 人 FACS 宿主: 小鼠 Monoclonal TU66 FITC
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
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别名
- CD39
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背景
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ATPDase, DKFZp686D194, DKFZp686I093, Ecto apyrase, Ecto ATP diphosphohydrolase, Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, FLJ40921, FLJ40959, Lymphoid cell activation antigen, NTPDase 1, SPG64
Human tonsil, placenta, kidney or lymph node.
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分子量
- 70-100 kDa
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基因ID
- 953, 576612
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UniProt
- P49961
抗原
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