CD39 抗体 (Extracellular Loop)
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Quick Overview for CD39 抗体 (Extracellular Loop) (ABIN7043112)
抗原
See all CD39 (ENTPD1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 398-411, Extracellular Loop
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原理
- A Rabbit Polyclonal Antibody to CD39
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交叉反应
- 人, 小鼠
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预测反应
- 14 amino acid residues identical, rat - 11,Mouse - 12
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产品特性
- Anti-CD39 (extracellular) Antibody (ABIN7043112, ABIN7044809 and ABIN7044810) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and indirect live cell flow cytometry applications. It has been designed to recognize ENTPD1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KTSYAGVKEKYLSE, corresponding to amino acid residues 398-411 of human CD39
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亚型
- IgG
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anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 1-180) antibody
ENTPD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 300-350) antibodyENTPD1 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR285L unconjugated Recombinant Antibody
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 38-179) antibodyENTPD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8E9F2 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 38-179) antibodyENTPD1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6H12F9 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibodyENTPD1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 241-486) antibodyENTPD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) (AA 316-474) antibodyENTPD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibodyENTPD1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibody (FITC)ENTPD1 适用: 人 FACS 宿主: 小鼠 Monoclonal TU66 FITC
anti-Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibody (APC)ENTPD1 适用: 人 FACS 宿主: 小鼠 Monoclonal TU66 APC
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应用备注
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WB: 1:200-1:400
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235254)
Blocking Peptide: (ABIN7235254)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
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别名
- ENTPD1
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背景
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Synonyms: Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase 1, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-apyrase, Lymphoid cell activation antigen, ENTPD1
Description: Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1, ENTPD1, or CD39) is an enzyme that catalyzes the phosphohydrolysis of extracellular adenosine triphosphate (eATP) and diphosphate (eADP), that are released following inflammatory stress and cell injury, to adenosine monophosphate (AMP). AMP is then used by the ecto-5'-nucleotidase CD73 to synthesize adenosine1.Hydrolysis of adenosine triphosphate and adenosine diphosphate, performed by CD39, suppresses the immune system and inhibits T-cell and Natural killer (NK) cell responses. This inhibition has a role in promoting Chronic lymphocytic leukemia (CLL) and hence it is proposed that blockade or inhibition of CD39 may be a target for new immune therapy for CLL2. CD39 activity is also related to the occurrence of calcific aortic valve disease (CAVD)3, and to various other types of immune responses4. In addition, CD39 plays a dominant role in the purinergic regulation of inflammation1.The transcription of CD39 is constitutive in microvascular endothelium and certain immune cells. The modulated expression of NTPDase1 has been closely associated with inflammatory cytokines, oxidative stress and hypoxia in vitro and in vivo5.Localization of CD39 within lipid rafts suggests that this ecto-enzyme may be involved in cell-cell contact and signaling6.CD39 is a part of the ectonucleoside triphosphate dyphosphohydrolases (eNTDPase) protein family which shares a unique structural feature: instead of being anchored in the membrane by a single transmembrane domain or lipid link like other ectoenzymes, these proteins contain two transmembrane domains, one at each end of the protein. The active site lies in the large extracellular region. In addition, all family members share a set of short sequences termed apyrase conserved regions (ACRs)7.
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基因ID
- 953
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NCBI登录号
- NM_001776
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UniProt
- P49961
抗原
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