Recombinant Clusterin 抗体
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Quick Overview for Recombinant Clusterin 抗体 (ABIN7865336)
抗原
See all Clusterin (CLU) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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Expression System
- CHO Cells
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原理
- Recombinant Clusterin / Apolipoprotein J (APO-J) (Marker of Anaplastic Large Cell Lymphoma) Antibody
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特异性
- Clusterin, also known as apolipoprotein J (ApoJ), complement lysis inhibitor (CLI), gp80, glycoprotein III, sulfated glycoprotein 2 (SGP2), SP40-40, testosterone-repressed prostate message 2 (TRPM2), and T64, is a secretory, heterodimeric glycoprotein of approximately 80 kD composed of two disulfide-linked subunits, alpha (residues 228,Äi449) and beta (residues 23,Äi227). It is synthesized as a 449-amino acid polypeptide and post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Clusterin interacts with a broad range of molecules and plays a role in diverse biological processes, including immune regulation, lipid transport, sperm maturation, complement cascade regulation, membrane recycling, cell adhesion, morphological transformation, tissue remodeling, and cell-cell interactions. It also influences ≤-amyloid structure and neuritic toxicity in vivo, suggesting a potential role in Alzheimer,Ä111s disease pathogenesis. Notably, Clusterin overexpression is more common in the late stages of mammary tumor progression.
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纯化方法
- 200ug/ml of Ab produced in CHO cell mammalian-based expression system.
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免疫原
- Prokaryotic recombinant protein corresponding to a portion of the alpha subunit of the human clusterin molecule.
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亚型
- IgG1, kappa
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anti-Clusterin (CLU) (AA 331-449) antibody
CLU 适用: 人, 大鼠, 小鼠 ELISA, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 229-446) antibodyCLU 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 227-448) antibodyCLU 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 228-449) antibodyCLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 226-447) antibodyCLU 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C10 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU 适用: 人 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 23-120) antibodyCLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 71-99), (N-Term) antibodyCLU 适用: 人, 大鼠, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB18701 unconjugated
anti-Clusterin (CLU) (AA 227-447) antibodyCLU 适用: 大鼠 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU 适用: 大鼠, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- Clusterin (CLU)
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别名
- Clusterin
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背景
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Aging associated protein 4, Apolipoprotein J, CLU1, CLU2, Clusterin alpha / beta chain, Complement associated protein SP40, Complement cytolysis inhibitor a chain, NA1/NA2, D14Ucla3, Dimeric acid glycoprotein, GP80, Ku70-binding protein 1 (KUB1), Sulfated glycoprotein 2 (SGP2), Testosterone repressed prostate message 2 (TPRM2B)
Human pancreas, tonsil or cervix.
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分子量
- 70kDa (precursor), 36-39kDa (alpha), 34-36kDa (beta)
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基因ID
- 1191, 436657
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UniProt
- P10909
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途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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