Recombinant BST2 抗体
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Quick Overview for Recombinant BST2 抗体 (ABIN7857735)
抗原
See all BST2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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Expression System
- CHO Cells
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原理
- Recombinant BST2 / Tetherin / CD317 (Target for Tumor Immunotherapy) Antibody
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特异性
- Bone marrow stromal cells act as regulators for B-cell growth and development through their surface molecules and cytokines. Bone marrow stromal antigen-2 (BST-2), also designated CD317 antigen, is a single-pass type II membrane protein. BST-2, which is expressed mainly on synovial cell lines and bone marrow stromal cell lines, is primarily expressed in liver, heart, placenta and lung tissues. BST-2 is thought to be involved in pre-B cell growth. It has been implicated in B cell activation in rheumatoid arthritis. IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.
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纯化方法
- 200ug/ml of Ab produced in CHO cell mammalian-based expression system.
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免疫原
- Recombinant BST2 protein
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亚型
- IgG, kappa
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anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) antibody
BST2 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 2E6 unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) antibodyBST2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) antibodyBST2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) antibodyBST2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H4 unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 49-161) antibodyBST2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) antibodyBST2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) antibodyBST2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (Internal Region) antibodyBST2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) antibodyKD Validated BST2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3405 unconjugated Recombinant Antibody
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-20) antibodyBST2 适用: 人, 小鼠 WB, FACS, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))
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别名
- BST2
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背景
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Bone Marrow Stromal Cell Antigen 2, NPC-A-7, PDCA-1
Human adrenal gland or ovary. HeLa, HEK293T or SiHa cells.
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分子量
- 30-36kDa
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基因ID
- 684
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UniProt
- Q10589
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途径
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
抗原
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