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Recombinant TCF4 抗体

The 兔 单克隆 anti-TCF4 antibody is suitable to detect TCF4 in samples from 人. It has been validated for WB.
产品编号 ABIN7828631
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for Recombinant TCF4 抗体 (ABIN7828631)

抗原

See all TCF4 抗体
TCF4 (Transcription Factor 4 (TCF4))

抗体类型

Recombinant Antibody

适用

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宿主

  • 53
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克隆类型

  • 43
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单克隆

标记

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This TCF4 antibody is un-conjugated

应用范围

  • 60
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Western Blotting (WB)

克隆位点

A730
  • 原理

    Recombinant TCF4 Monoclonal Antibody

    纯化方法

    Protein A purified

    亚型

    IgG, kappa
  • 应用备注

    WB 1:1000

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

    有效期

    12 months
  • 抗原

    TCF4 (Transcription Factor 4 (TCF4))

    别名

    TCF4

    背景

    FECD,bHLHb,SEF,ITF,TCF,TCF4,E2-2,FECD3,ITF-2,ITF2,PTHS,SEF-2,SEF2,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,TCF-4,bHLHb19,Transcription factor 4 (TCF4), also known as SEF2, ITF2, E2-2, and ME2, binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription By similarity. Human TCF4 mRNA expression is particularly high in the brain. Usage of numerous 5' exons of the human TCF4 gene potentially yields in TCF4 protein isoforms with 18 different N-termini. In addition, the diversity of isoforms is increased by alternative splicing of several internal exons. Some isoforms contain a bipartite nuclear localization signal and are exclusively nuclear, whereas distribution of other isoforms relies on heterodimerization partners. TCF4 preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.TCF4 has several splicing isoforms that are expressed differentially in tissues and during cancer progression. The scopel of molecular weight of several isoforms is about 60-90 kDa. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

    分子量

    Calculated MW: 71 kDa

    Observed MW: 62 kDa The actual band is not consistent with the expectation.

    UniProt

    P15884

    途径

    WNT signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
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