Recombinant PKN1 抗体
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北京 101111
Quick Overview for Recombinant PKN1 抗体 (ABIN7828497)
抗原
See all PKN1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant PKN1 Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human PKN1 fragment
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亚型
- IgG, kappa
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anti-Protein Kinase N1 (PKN1) (AA 462-615) antibody
PKN1 适用: 人 WB, ELISA, IF, IP, RNAi 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 442-620) antibodyPKN1 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4H10B1 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 615-874) antibodyPKN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 836-870) antibodyPKN1 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB56692 unconjugated
anti-Protein Kinase N1 (PKN1) antibodyKD Validated PKN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1505 unconjugated Recombinant Antibody
anti-Protein Kinase N1 (PKN1) (AA 1-942) antibodyPKN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (Internal Region) antibodyPKN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-942) antibodyPKN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (Center) antibodyPKN1 适用: 人, 小鼠, Cow, 猴 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- PKN1 (Protein Kinase N1 (PKN1))
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别名
- PKN1
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背景
- PRK,PRKCL,PAK,PKN1,DBK,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1,Protein kinase N1,PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 120 kDa
Observed MW: 120 kDa
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UniProt
- Q16512
抗原
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